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Chemical Structure : GSK180
CAS No.: 1799725-26-0
Catalog No.: PC-35240Not For Human Use, Lab Use Only.
GSK180 (GSK-180) is a potent and specific inhibitor of kynurenine-3-monooxygenase (KMO) with IC50 of 6 nM, shows negligible activity against other enzymes on the tryptophan pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $585 | In stock | |
| 100 mg | $1280 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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GSK180 (GSK-180) is a potent and specific inhibitor of kynurenine-3-monooxygenase (KMO) with IC50 of 6 nM, shows negligible activity against other enzymes on the tryptophan pathway; inhibits the convertion of kynurenine to 3-hydroxykynurenine with IC50 of 2.0 uM in cell-based assays; prevents multiple organ failure in rodent models of acute pancreatitis.
| M.Wt | 276.07 | |
| Formula | C10H7Cl2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(5,6-dichloro-2-oxo-1,3-benzoxazol-3-yl)propanoic acid |
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1. Mole DJ, et al. Nat Med. 2016 Feb;22(2):202-9.
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