GSK180736A | GRK2 inhibitor | Probechem Biochemicals

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Chemical Structure : GSK180736A

CAS No.: 817194-38-0

GSK180736A (GSK 180736A, GSK-180736A)

Catalog No.: PC-45590Not For Human Use, Lab Use Only.

GSK180736A is a highly selective and potent GRK2 inhibitor with IC50 of 0.77 uM.

Packing	Price	Stock
10 mg	$78	In stock
25 mg	$138	In stock
50 mg	$248	In stock
100 mg		Get quote

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK180736A is a highly selective and potent GRK2 inhibitor with IC50 of 0.77 uM.
GSK180736A displays >400-fold selective for GRK2 over both GRK1 and GRK5, with no inhibition on PKA; also inhibits ROCK with IC50 of 0.1 uM.

Physicochemical Properties

M.Wt	365.3611
Formula	C19H16FN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	5-Pyrimidinecarboxamide, 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-

References

1. Homan KT, et al. ACS Chem Biol. 2015 Jan 16;10(1):310-9.

2. Waldschmidt HV, et al. J Med Chem. 2016 Apr 28;59(8):3793-807.

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GSK180736A (GSK 180736A, GSK-180736A)

Biological Activity

Physicochemical Properties

References

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