GSK1842799 | S1P1 agonist | Probechem Biochemicals

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Chemical Structure : GSK1842799

GSK1842799 (GSK 1842799)

Catalog No.: PC-61604Not For Human Use, Lab Use Only.

GSK1842799 is a potent, selective, oral bioavailable S1P1 agonist with bind affinity of 0.52 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK1842799 is a potent, selective, oral bioavailable S1P1 agonist with bind affinity of 0.52 nM.
GSK1842799 displays an excellent selectivity (>3,000-fold) for S1P1 over S1P3.
GSK1842799 significantly reduces blood lymphocyte at 3 mg/kg, achieves efficacy equivalent to FTY720 in the mouse EAE model of MS.

Physicochemical Properties

M.Wt	431.518
Formula	C20H28F3N3O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-2-(5-(4-(octyloxy)-3-(trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)propan-1-ol

References

1. Deng H, et al. ACS Med Chem Lett. 2013 Aug 27;4(10):942-7.

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GSK1842799 (GSK 1842799)

Biological Activity

Physicochemical Properties

References

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