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Chemical Structure : GSK199
CAS No.: 1549810-81-2
Catalog No.: PC-62216Not For Human Use, Lab Use Only.
GSK199 is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $378 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK199 is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay.
GSK199 shows high specificity for PAD4 over PAD1/2/3/6.
GSK199 affects cellular citrullination and mimic the deficiency in NET production in mice.
GSK199 significantly decreases in complement C3 deposition in both synovium and cartilage in mice.
| M.Wt | 432.528 | |
| Formula | C24H28N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[(3R)-3-amino-1-piperidinyl][2-(1-ethyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone |
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1. Lewis HD, et al. Nat Chem Biol. 2015 Mar;11(3):189-91.
2. Willis VC, et al. Clin Exp Immunol. 2017 May;188(2):263-274.
3. Slade DJ, et al. ACS Chem Biol. 2015 Apr 17;10(4):1043-53.
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