Catalog No.: PC-62217Not For Human Use, Lab Use Only.
GSK199 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay.
GSK199 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay.
GSK199 shows high specificity for PAD4 over PAD1/2/3/6.
GSK199 affects cellular citrullination and mimic the deficiency in NET production in mice.
GSK199 significantly decreases in complement C3 deposition in both synovium and cartilage in mice.
GSK199 also inhibits human beta-coronaviruse HCoV-OC43 replication.
