Catalog No.: PC-70008Not For Human Use, Lab Use Only.
GSK2181236A is a potent, selective soluble guanylate cyclase (sGC) stimulator that increases sGC activity (cGMP formation) with EC50s of 27 and 25 nM for rat and human sGC, respectively.
GSK2181236A is a potent, selective soluble guanylate cyclase (sGC) stimulator that increases sGC activity (cGMP formation) with EC50s of 27 and 25 nM for rat and human sGC, respectively.
GSK2181236A displays 23-fold selectivity for sGC over OATP1B1 and >197-fold selectivity over a panel of 38 proteins.
GSK2181236A increases P-VASP levels in rat aortic smooth muscle cells with EC50 of 12.7 nM.
GSK2181236A attenuates the development of cardiac hypertrophy in a blood pressure-independent fashion.
