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Chemical Structure : GSK2181236A
Catalog No.: PC-70008Not For Human Use, Lab Use Only.
GSK2181236A is a potent, selective soluble guanylate cyclase (sGC) stimulator that increases sGC activity (cGMP formation) with EC50s of 27 and 25 nM for rat and human sGC, respectively.
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GSK2181236A is a potent, selective soluble guanylate cyclase (sGC) stimulator that increases sGC activity (cGMP formation) with EC50s of 27 and 25 nM for rat and human sGC, respectively.
GSK2181236A displays 23-fold selectivity for sGC over OATP1B1 and >197-fold selectivity over a panel of 38 proteins.
GSK2181236A increases P-VASP levels in rat aortic smooth muscle cells with EC50 of 12.7 nM.
GSK2181236A attenuates the development of cardiac hypertrophy in a blood pressure-independent fashion.
| M.Wt | 613.14 | |
| Formula | C31H21F6N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Costell MH, et al. Front Pharmacol. 2012 Jul 5;3:128.
2. Stasch JP, et al. Curr Opin Pharmacol. 2015 Apr;21:95-104.
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