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Chemical Structure : GSK2190915
CAS No.: 936350-00-4
Catalog No.: PC-44768Not For Human Use, Lab Use Only.
Fiboflapon (AM-803, GSK 2190915) is a potent, selective 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 2.6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Fiboflapon (AM-803, GSK 2190915) is a potent, selective 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 2.6 nM.
Fiboflapon (AM-803, GSK 2190915) inhibits LTB4 synthesis following ionophore challenge in human whole blood with IC50 of 76 nM (5 h incubation).
Fiboflapon (AM-803, GSK 2190915) shows good selectivity over CYP3A4, 2C9, and 2D6.
Fiboflapon (AM-803, GSK 2190915) exhibits excellent preclinical toxicology, pharmacokinetics and oral bioactivity.
| M.Wt | 637.8307 | |
| Formula | C38H43N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-ethoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-[(5-methyl-2-pyridinyl)methoxy]- |
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1. Stock NS, et al. J Med Chem. 2011 Dec 8;54(23):8013-29.
2. Lorrain DS, et al. Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8.
3. Kent SE, et al. Clin Exp Allergy. 2013 Feb;43(2):177-86.
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