GSK235 | ERAP1 inhibitor | Probechem Biochemicals

Chemical Structure : GSK235

GSK235 (GSK-235)

Catalog No.: PC-27081Not For Human Use, Lab Use Only.

GSK235 is a potent, selective and orally available inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1) with biochemical pIC50 of 8.45, shows >1000-fold selectivity over ERAP2/IRAP.

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Biological Activity

GSK235 is a potent, selective and orally available inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1) with biochemical pIC50 of 8.45, shows >1000-fold selectivity over ERAP2/IRAP.
GSK235 regulates the immunopeptidome of cancer cells, and enhances tumor antigenicity in vivo controlling growth.

Physicochemical Properties

M.Wt	386.50
Formula	C21H30N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3R,4R)-1-(3-cyano-4-methyl-6-((4-methyltetrahydro-2H-pyran-4-yl)amino)pyridin-2-yl)-4-isopropylpyrrolidine-3-carboxylic acid

References

1. Tinworth CP, et al. J Med Chem. 2026 Jun 21. doi: 10.1021/acs.jmedchem.6c00029.

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GSK235 (GSK-235)

Biological Activity

Physicochemical Properties

References

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