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Chemical Structure : GSK256073
CAS No.: 862892-90-8
Catalog No.: PC-21439Not For Human Use, Lab Use Only.
GSK256073 is a highly potent, selective agonist of hydroxy-carboxylic acid receptor 2 (HCA2, HM74A/GPR109A) with pEC50 of 7.5, 100-fold selective over HCA3 (pEC50=5.6).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $478 | In stock | |
| 100 mg | Get quote |
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GSK256073 is a highly potent, selective agonist of hydroxy-carboxylic acid receptor 2 (HCA2, HM74A/GPR109A) with pEC50 of 7.5, 100-fold selective over HCA3 (pEC50=5.6).
GSK256073 is a full and potent agonist (pEC50=6.48) at human adipocyte membranes using a [35S]GTP-γS binding assay.
GSK256073 does not display significant activity against a number of 7-transmembrane receptors, ion channels, transporters, and phophodiesterases.
GSK256073 (0.03, 0.3, 3.0 and 30 mg/kg) inhibited triglyceride accumulation by 7%, 30%, 51% and 78%, respectively, in rats.
| M.Wt | 256.69 | |
| Formula | C10H13ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-chloro-3-pentyl-7H-purine-2,6-dione |
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1. Sprecher D, et al. Eur J Pharmacol. 2015 Jun 5;756:1-7.
2. Dobbins R, et al. Eur J Pharmacol. 2015 May 15;755:95-101.
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