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Chemical Structure : GSK2593074A
CAS No.: 1337531-06-2
Catalog No.: PC-36135Not For Human Use, Lab Use Only.
GSK2593074A (GSK'074, GSK-2593074A) is novel potent, selective RIP1/RIP3 kinase dual inhibitor, directly binds to RIP1 and RIP3 with Kd of 130 and 12 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK2593074A (GSK'074, GSK-2593074A) is novel potent, selective RIP1/RIP3 kinase dual inhibitor, directly binds to RIP1 and RIP3 with Kd of 130 and 12 nM, respectively.
GSK2593074A potently inhibits necroptosis in various cell types (IC50=3 nM both in MOVAS and L929 cells), blocks necroptosis signaling pathway.
GSK2593074A inhibits RIP3-dependent RIP1-independent necroptosis and inflammation, but does not induce apoptosis.
GSK2593074A attenuates cell death and inflammation in calcium phosphate injured aortae.
| M.Wt | 465.575 | |
| Formula | C27H23N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-(5-(4-amino-7-(1-methyl-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl)indolin-1-yl)-2-phenylethan-1-one |
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1. Zhou T, et al. Cell Death Dis. 2019 Mar 6;10(3):226.
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