Catalog No.: PC-36135Not For Human Use, Lab Use Only.
GSK2593074A (GSK'074, GSK-2593074A) is novel potent, selective RIP1/RIP3 kinase dual inhibitor, directly binds to RIP1 and RIP3 with Kd of 130 and 12 nM, respectively.
GSK2593074A (GSK'074, GSK-2593074A) is novel potent, selective RIP1/RIP3 kinase dual inhibitor, directly binds to RIP1 and RIP3 with Kd of 130 and 12 nM, respectively.
GSK2593074A potently inhibits necroptosis in various cell types (IC50=3 nM both in MOVAS and L929 cells), blocks necroptosis signaling pathway.
GSK2593074A inhibits RIP3-dependent RIP1-independent necroptosis and inflammation, but does not induce apoptosis.
GSK2593074A attenuates cell death and inflammation in calcium phosphate injured aortae.
