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Chemical Structure : GSK2606414
CAS No.: 1337531-36-8
Catalog No.: PC-45410Not For Human Use, Lab Use Only.
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM.
GSK2606414 inhibits PERK activation in cells and inhibits the growth of human tumor xenograft in mice.
GSK2606414 reduces p-eIF2α levels and enhanced novel taste learning and conditioned taste aversion, but not memory retrieval in rats.
| M.Wt | 451.4437 | |
| Formula | C24H20F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Ethanone, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]- |
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1. Axten JM, et al. J Med Chem. 2012 Aug 23;55(16):7193-207.
2. Ounallah-Saad H, et al. J Neurosci. 2014 Oct 29;34(44):14624-32.
3. Guthrie LN, et al. J Biol Chem. 2016 Jul 22;291(30):15830-40.
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