Catalog No.: PC-24391Not For Human Use, Lab Use Only.
GSK269962A is a potent, selective Rho kinase (ROCK) inhibitor with IC50 of 1.6 nM (recombinant human ROCK1), 30-fold selectivity against a panel of serine/threonine kinases.
GSK269962A is a potent, selective Rho kinase (ROCK) inhibitor with IC50 of 1.6 nM (recombinant human ROCK1), 30-fold selectivity against a panel of serine/threonine kinases. GSK269962 blocked the generation of inflammatory cytokines, such as interleukin-6 and tumor necrosis factor-alpha in lipopolysaccharide-stimulated monocytes. GSK269962A induced vasorelaxation in preconstricted rat aorta with an IC50 of 39 and 35 nM, respectively. GSK269962 produced a profound dose-dependent reduction of systemic blood pressure in spontaneously hypertensive rats, induced a reduction in blood pressure of approximately 10, 20, and 50 mm Hg at 1, 3, and 30 mg/kg.
