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GSK 2793660

Chemical Structure : GSK 2793660

CAS No.: 1613458-79-9

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GSK 2793660 (GSK2793660;GSK-2793660)

Catalog No.: PC-60946Not For Human Use, Lab Use Only.

GSK 2793660 (GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C (CTSC) inhibitor with IC50 of 0.43-1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GSK 2793660 (GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C (CTSC) inhibitor with IC50 of 0.43-1 nM.
    GSK 2793660 does not inhibits the activity of downstream neutrophil serine proteases.
    GSK 2793660 shows potential for the treatment of cystic fibrosis, non-cystic fibrosis bronchiectasis, ANCA-associated vasculitis and bronchiectasis.

    Physicochemical Properties

    M.Wt 421.966
    Formula C22H32ClN3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S,E)-4-amino-N-(1-(indolin-1-yl)-6-methyl-1-oxohept-2-en-4-yl)tetrahydro-2H-pyran-4-carboxamide hydrochloride

    References

    1. Miller BE, et al. Br J Clin Pharmacol. 2017 Dec;83(12):2813-2820.

    2. Szcześniak P, et al. J Org Chem. 2016 Feb 5;81(3):1057-74.

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