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Chemical Structure : GSK 2793660
Catalog No.: PC-60946Not For Human Use, Lab Use Only.
GSK 2793660 (GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C (CTSC) inhibitor with IC50 of 0.43-1 nM.
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GSK 2793660 (GSK2793660) is a potent, selective, irreversible and orally bioavailable cathepsin C (CTSC) inhibitor with IC50 of 0.43-1 nM.
GSK 2793660 does not inhibits the activity of downstream neutrophil serine proteases.
GSK 2793660 shows potential for the treatment of cystic fibrosis, non-cystic fibrosis bronchiectasis, ANCA-associated vasculitis and bronchiectasis.
| M.Wt | 421.966 | |
| Formula | C22H32ClN3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Miller BE, et al. Br J Clin Pharmacol. 2017 Dec;83(12):2813-2820.
2. Szcześniak P, et al. J Org Chem. 2016 Feb 5;81(3):1057-74.
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