GSK2818713 | HCV NS5A inhibitor | Probechem Biochemicals

Chemical Structure : GSK2818713

GSK2818713 (GSK-2818713)

Catalog No.: PC-72397Not For Human Use, Lab Use Only.

GSK2818713 (GSK-2818713) is a nonstructural protein 5A (NS5A) HCV inhibitor with broad genotype coverage.

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Biological Activity

GSK2818713 (GSK-2818713) is a nonstructural protein 5A (NS5A) HCV inhibitor with broad genotype coverage.
GSK2818713 significantly improved genotype coverage relative to first-generation NS5A inhibitor daclatasvir (DCV).
GSK2818713 improved activity against genotype 1a (gt1a) and gt1b NS5A variants as well as HCV chimeric replicons containing NS5A fragments from genotypes 2-6.
GSK2818713 potently and durably decreased HCV RNA levels for gt1a, gt2a, and gt3a in replicon assays.

Physicochemical Properties

M.Wt	C46H56N8O8
Formula	849.002
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	dimethyl ((2S,2'S,3R,3'R)-((2S,2'S,3aS,3a'S,6aS,6a'S)-(biphenylene-2,6-diylbis(1H-imidazole-5,2-diyl))bis(hexahydrocyclopenta[b]pyrrole-2,1(2H)-diyl))bis(3-methoxy-1-oxobutane-1,2-diyl))dicarbamate

References

1. Wieslaw M Kazmierski, et al. J Med Chem. 2020 Apr 23;63(8):4155-4170.

GSK2818713 (GSK-2818713)

Biological Activity

Physicochemical Properties

References

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