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Chemical Structure : GSK2983559-AM
CAS No.: 1423186-80-4
Catalog No.: PC-73179Not For Human Use, Lab Use Only.
GSK2983559-AM is the acitve form of GSK2983559, a potent, selective RIPK2 with IC50 of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $258 | In stock | |
| 25 mg | $428 | In stock | |
| 100 mg | $988 | In stock | |
| 200 mg | $1580 | In stock | |
| 1 g | Get quote |
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GSK2983559-AM is the acitve form of GSK2983559, a potent, selective RIPK2 with IC50 of 5 nM.
GSK2983559-AM potently and dose dependently inhibited MDP-stimulated IL-8 production in HEK293 cells and TNFα production in monocytes with IC50 of 4 nM and 13 nM, respectively.
GSK2983559-AM displays little to no effect against a panel of other innate immune receptors, including TNFR, IL1R and TLR2/4/7/9 (IC50>10 uM).
The prodrug GSK2983559 reduced inflammation, edema, and goblet cell depletion in a murine TNBS colitis model.
| M.Wt | 458.551 | |
| Formula | C21H22N4O4S2 | |
| Appearance | Solid | |
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| Chemical Name/SMILES |
2-[[4-(5-Benzothiazolylamino)-6-[(1,1-dimethylethyl)sulfonyl]-7-quinazolinyl]oxy]ethanol |
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1. Pamela A Haile, et al. J Med Chem. 2019 Jul 25;62(14):6482-6494.
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