GSK3008348 | αvβ6 integrin inhibitor

Chemical Structure : GSK3008348

CAS No.: 1629249-33-7

GSK3008348 (GSK-3008348)

Catalog No.: PC-60069Not For Human Use, Lab Use Only.

GSK3008348 is a potent, selective, RGD-mimetic integrin αvβ6 antagonist with KD value of 9.5 pM and 4.8 pM for αvβ6 in normal and IPF human lung tissue membrane preparations.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
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Biological Activity

GSK3008348 is a potent, selective, RGD-mimetic integrin αvβ6 antagonist with KD value of 9.5 pM and 4.8 pM for αvβ6 in normal and IPF human lung tissue membrane preparations.

GSK3008348 exhibits a high affinity and a minimum of 26-fold selectivity for the αvβ6 integrin over the other RGD integrin family members.

GSK3008348 induces αvβ6 internalization and degradation in human lung epithelial cells.

GSK3008348 engages αvβ6, induces prolonged inhibition of TGFβ signaling and reduces lung collagen deposition and serum C3M, a marker of IPF disease progression, in murine bleomycin-induced lung fibrosis model.

Physicochemical Properties

M.Wt	487.636
Formula	C29H37N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-3-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl]-4-{(3S)-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-1-pyrrolidinyl}butanoic acid

References

1. John AE, et al. Nat Commun. 2020 Sep 16;11(1):4659.

GSK3008348 (GSK-3008348)

Biological Activity

Physicochemical Properties

References

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