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Chemical Structure : GSK321
CAS No.: 1816331-63-1
Catalog No.: PC-70088Not For Human Use, Lab Use Only.
GSK321 is a highly potent, selective inhibitor of mutant IDH1 with IC50s of 4.6/3.8/2.9 nM for R132H/R132C/R132G respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK321 is a highly potent, selective inhibitor of mutant IDH1 with IC50s of 4.6/3.8/2.9 nM for R132H/R132C/R132G respectively.
GSK321 shows modest activity against WT IDH1 (IC50=46 nM) and exhibits no inhibitory activity against IDH2.
GSK321 inhibits intracellular 2-HG production in HT1080 cells (EC50= 85 nM).
| M.Wt | 501.5624 | |
| Formula | C28H28FN5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-1-(4-fluorobenzyl)-N-(3-((S)-1-hydroxyethyl)phenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide |
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1. Okoye-Okafor UC, et al. Nat Chem Biol. 2015 Nov;11(11):878-86.
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