Chemical Structure : GSK321
CAS No.:
1816331-63-1
GSK321
(GSK-321, GSK 321)
Catalog No. : PC-70088Not For Human Use, Lab Use Only.
GSK321 is a highly potent, selective inhibitor of mutant IDH1 with IC50s of 4.6/3.8/2.9 nM for R132H/R132C/R132G respectively.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-7008801
Biological Activity
GSK321 is a highly potent, selective inhibitor of mutant IDH1 with IC50s of 4.6/3.8/2.9 nM for R132H/R132C/R132G respectively.
Physicochemical Properties
M.Wt
501.5624
Formula
C28H28FN5O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(R)-1-(4-fluorobenzyl)-N-(3-((S)-1-hydroxyethyl)phenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide
References
1. Okoye-Okafor UC, et al. Nat Chem Biol
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