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GSK 356278

Chemical Structure : GSK 356278

CAS No.: 720704-34-7

GSK 356278 (GSK356278;GSK-356278)

Catalog No.: PC-60657Not For Human Use, Lab Use Only.

A potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective, brain-penetrant and orally bioavailable phosphodiesterase 4 (PDE4) inhibitor with pIC50 of 8.8 (PDE4B); equally inhibits PDE4A and PDE4Dwith pIC50 of 8.6 and 8.7, exhibits >100-fold selectivity for PDE4B over the other 10 PDEs; inhibits LPS-induced release of TNF-α in human whole blood with pIC50 of 7.6, demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in models of anxiety.

Anxiety

Phase 1 Clinical

Physicochemical Properties

M.Wt 439.538
Formula C21H25N7O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(5-((2,4-dimethylthiazol-5-yl)methyl)-1,3,4-oxadiazol-2-yl)-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine

References

1. Rutter AR, et al. J Pharmacol Exp Ther. 2014 Jul;350(1):153-63.

2. van der Aart J, et al. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17720868.

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