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GSK 366

Chemical Structure : GSK 366

CAS No.: 1953157-39-5

GSK 366 (GSK-366;GSK366)

Catalog No.: PC-61184Not For Human Use, Lab Use Only.

A novel potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50 of 2.3 nM and 0.7 nM for human KMO and Pf-KMO, respectively..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A novel potent kynurenine-3-monooxygenase (KMO) inhibitor with IC50 of 2.3 nM and 0.7 nM for human KMO and Pf-KMO, respectively.

Physicochemical Properties

M.Wt 361.782
Formula C17H16ClN3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-3-(5-chloro-6-(1-(6-methylpyridazin-3-yl)ethoxy)benzo[d]isoxazol-3-yl)propanoic acid

References

1. Hutchinson JP, et al. Nat Commun. 2017 Jun 12;8:15827.

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