GSK429286A | ROCK inhibitor | Probechem Biochemicals

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Chemical Structure : GSK429286A

CAS No.: 864082-47-3

GSK429286A (GSK 429286A;GSK-429286A)

Catalog No.: PC-42776Not For Human Use, Lab Use Only.

GSK429286A is a poten and selective inhibitor ROCK1 (IC50=14 nM) and ROCK2 (IC50=63 nM).

Packing	Price	Stock
5 mg (Free Sample)	$28	In stock
25 mg	$138	In stock
50 mg	$248	In stock
100 mg	$398	In stock
250 mg		Get quote

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK429286A is a poten and selective inhibitor ROCK1 (IC50=14 nM) and ROCK2 (IC50=63 nM).
GSK429286A inhibits RSK and p70S6K with IC50 of 0.78 μM and 1.94 μM, respectively.
GSK429286A has oral bioavailability.

Physicochemical Properties

M.Wt	432.3709
Formula	C21H16F4N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 51 mg/mL
Chemical Name/SMILES	3-Pyridinecarboxamide, N-(6-fluoro-1H-indazol-5-yl)-1,4,5,6-tetrahydro-2-methyl-6-oxo-4-[4-(trifluoromethyl)phenyl]-

References

1. Goodman KB, et al. J Med Chem. 2007 Jan 11;50(1):6-9.

2. Nichols RJ, et al. Biochem J, 2009, 424(1), 47-60.

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GSK429286A (GSK 429286A;GSK-429286A)

Biological Activity

Physicochemical Properties

References

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