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Chemical Structure : GSK461364
CAS No.: 929095-18-1
Catalog No.: PC-45884Not For Human Use, Lab Use Only.
GSK461364 is a potent, selective, and reversible ATP-competitive PLK1 inhibitor with Ki of 2.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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GSK461364 is a potent, selective, and reversible ATP-competitive PLK1 inhibitor with Ki of 2.2 nM.
GSK461364 displays >390-fold greater selectivity for Plk1 than for Plk2 and Plk3 and 1,000-fold greater selectivity than for a panel of 48 other kinases.
GSK461364 shows antiproliferative activity against >120 tumor cell lines and potently inhibits the proliferation with IC50s of <100 nM.
GSK461364 shows clear antitumor activity in human tumor xenograft models.
| M.Wt | 543.6038 | |
| Formula | C27H28F3N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Thiophenecarboxamide, 5-[6-[(4-methyl-1-piperazinyl)methyl]-1H-benzimidazol-1-yl]-3-[(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy]- |
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1. Olmos D, et al. Clin Cancer Res. 2011 May 15;17(10):3420-30.
2. Gilmartin AG, et al. Cancer Res. 2009 Sep 1;69(17):6969-77.
3. Degenhardt Y, et al. Mol Cancer Ther. 2010 Jul;9(7):2079-89.
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