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Chemical Structure : GSK484
CAS No.: 1652629-23-6
Catalog No.: PC-62214Not For Human Use, Lab Use Only.
GSK484 is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), 50 nM in PAD4 NH3 release inhibition assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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GSK484 is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), 50 nM in PAD4 NH3 release inhibition assay.
GSK484 shows high specificity for PAD4 over PAD1/2/3/6.
GSK484 causes a clear, statistically-significant reduction in diffused NETs.
| M.Wt | 473.577 | |
| Formula | C27H31N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[(3S,4R)-3-amino-4-hydroxy-1-piperidinyl][2-[1-(cyclopropylmethyl)-1H-indol-2-yl]-7-methoxy-1-methyl-1H-benzimidazol-5-yl]-methanone |
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1. Lewis HD, et al. Nat Chem Biol. 2015 Mar;11(3):189-91.
2. Cedervall J, et al. Oncoimmunology. 2017 Apr 20;6(8):e1320009.
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