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GSK635416A

Chemical Structure : GSK635416A

CAS No.: 944729-29-7

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GSK635416A (GSK-635416A)

Catalog No.: PC-62548Not For Human Use, Lab Use Only.

GSK 635416A is a novel ATM inhibitor with highly selective radiosensitizing activity, inhibits radiation induced phosphorylation of ATM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GSK635416A is a novel ATM inhibitor with highly selective radiosensitizing activity, inhibits radiation induced phosphorylation of ATM.
    GSK635416A exhibits virtually no cytotoxicity in the absence of radiation and in normal fibroblast cells.
    GSK635416A enhances IR effect in radiosensitizing HNSCC cell lines but not in normal fibroblast BJ-ET cells in combined with olaparib.

    Physicochemical Properties

    M.Wt 453.532
    Formula C24H24FN3O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-amino-5-(4-fluorophenyl)-N-methyl-3-(4-pyrrolidin-1-ylsulfonylphenyl)benzamide

    References

    1. Dohmen AJC, et al. Oncotarget. 2017 May 19;8(43):73925-73937.

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