GSK 635416A |CAS:944729-29-7 Probechem Biochemicals

Chemical Structure : GSK 635416A

GSK 635416A (GSK635416A)

Catalog No.: PC-62548Not For Human Use, Lab Use Only.

GSK 635416A is a novel ATM inhibitor with highly selective radiosensitizing activity, inhibits radiation induced phosphorylation of ATM.

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Biological Activity

GSK 635416A is a novel ATM inhibitor with highly selective radiosensitizing activity, inhibits radiation induced phosphorylation of ATM; exhibits virtually no cytotoxicity in the absence of radiation and in normal fibroblast cells, enhances IR effect in radiosensitizing HNSCC cell lines but not in normal fibroblast BJ-ET cells in combined with olaparib.

Physicochemical Properties

M.Wt	453.532
Formula	C24H24FN3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-5-(4-fluorophenyl)-N-methyl-3-(4-pyrrolidin-1-ylsulfonylphenyl)benzamide

References

1. Dohmen AJC, et al. Oncotarget. 2017 May 19;8(43):73925-73937.

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GSK 635416A (GSK635416A)

Biological Activity

Physicochemical Properties

References

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