GSK682753A (GSK 682753A, GSK-682753A) is a potent, selective EBI-2 (GPR183) inhibitor with IC50 of 53.6 nM.
GSK682753A displays high selectivity over other constitutively active receptors, including GPR39, the ghrelin receptor, GPR17, MC1R, and ORF74.
GSK682753A does not affect the cell surface expression of EBI2 in HEK293 cells.
GSK682753A dose-dependently suppresses the inhibition of forskolin-stimulated cAMP accumulation mediated by EBI2 with IC50 of 10.9 nM, inhibits EBI2-mediated ERK phosphorylation with IC50 of 76 nM.
GSK682753A inhibits the antibody-induced proliferation of murine WT B cells.
