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Chemical Structure : GSK726701A
Catalog No.: PC-63350Not For Human Use, Lab Use Only.
GSK726701A is a novel potent, selective EP4 receptor partial agonist with pEC50 of 7.4 in cAMP accumulation assay, >100-fold against a set of other prostaglandin receptors (EP1-3, DP1, FP, IP and TP).
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GSK726701A is a novel potent, selective EP4 receptor partial agonist with pEC50 of 7.4 in cAMP accumulation assay, >100-fold against a set of other prostaglandin receptors (EP1-3, DP1, FP, IP and TP).
GSK726701A has low human CYP inhibition potential and low intrinsic clearance across species.
GSK726701A demonstrates robust activity in a range of pre-clinical models of pain.
| M.Wt | 423.44 | |
| Formula | C24H22FNO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Healy MP, et al. Bioorg Med Chem Lett. 2018 Mar 31. pii: S0960-894X(18)30296-8.
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