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Chemical Structure : GSK840
CAS No.: 2361146-30-5
Catalog No.: PC-21478Not For Human Use, Lab Use Only.
GSK840 is a specific small-molecule inhibitor of RIPK3 with IC50 of 0.9 nM, specifically inhibit RIPK3/MLKL-dependent necroptosis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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GSK840 is a specific small-molecule inhibitor of RIPK3 with IC50 of 0.9 nM, specifically inhibit RIPK3/MLKL-dependent necroptosis.
GSK840 blocks TNF-induced necroptosis in a concentration-dependent manner.
GSK840 binds RIP3 kinase domain with IC50 of 0.9 nM, and inhibits kinase activity with IC50 of 0.3 nM.
| M.Wt | 365.43 | |
| Formula | C21H23N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
tert-butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate |
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1. Mandal P, et al. Mol Cell. 2014 Nov 20;56(4):481-95.
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