GSK840 | RIPK3 inhibitor | Probechem Biochemicals

Chemical Structure : GSK840

CAS No.: 2361146-30-5

GSK840 (GSK'840, GSK-840)

Catalog No.: PC-21478Not For Human Use, Lab Use Only.

GSK840 is a specific small-molecule inhibitor of RIPK3 with IC50 of 0.9 nM, specifically inhibit RIPK3/MLKL-dependent necroptosis.

Packing	Price	Stock
10 mg	$98	In stock
25 mg	$158	In stock
50 mg	$238	In stock
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Biological Activity

GSK840 is a specific small-molecule inhibitor of RIPK3 with IC50 of 0.9 nM, specifically inhibit RIPK3/MLKL-dependent necroptosis.
GSK840 blocks TNF-induced necroptosis in a concentration-dependent manner.
GSK840 binds RIP3 kinase domain with IC50 of 0.9 nM, and inhibits kinase activity with IC50 of 0.3 nM.

Physicochemical Properties

M.Wt	365.43
Formula	C21H23N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	tert-butyl 2-(4-(5-(methylcarbamoyl)-1H-benzo[d]imidazol-1-yl)phenyl)acetate

References

1. Mandal P, et al. Mol Cell. 2014 Nov 20;56(4):481-95.

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GSK840 (GSK'840, GSK-840)

Biological Activity

Physicochemical Properties

References

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