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Chemical Structure : GSK864
CAS No.: 1816331-66-4
Catalog No.: PC-45645Not For Human Use, Lab Use Only.
GSK864 is a compound structurally related to GSK321 with improved in vivo pharmacokinetic properties, inhibits IDH1 mutants R132C, R132H, and R132G with IC50 values of 8.8, 15.2 and 16.6 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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GSK864 is a compound structurally related to GSK321 with improved in vivo pharmacokinetic properties, inhibits IDH1 mutants R132C, R132H, and R132G with IC50 values of 8.8, 15.2 and 16.6 nM, respectively.
GSK864 shows the similar activity (2-HG production in R132C IDH1 mutant HT1080 fibrosarcoma cells, EC50 of 320 nM).
GSK864 reduces leukemic blasts in vivo.
| M.Wt | 558.6033 | |
| Formula | C30H31FN6O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 100 mg/mL |
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| Chemical Name/SMILES |
(S)-1-(4-fluorobenzyl)-N3-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3,7-dicarboxamide |
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1. Okoye-Okafor UC, et al. Nat Chem Biol. 2015 Nov;11(11):878-86.
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