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GSK962040

Chemical Structure : GSK962040

CAS No.: 923565-21-3

GSK962040 (Camicinal, GSK-962040)

Catalog No.: PC-42738Not For Human Use, Lab Use Only.

GSK962040 (Camicinal) is a potent, selective, small molecule motilin receptor agonist with pEC50 of 7.9 (hMTL-R).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK962040 (Camicinal) is a potent, selective, small molecule motilin receptor (GPR38) agonist with pEC50 of 7.9 (hMTL-R).
GSK962040 displays selectivity over closely related human ghrelin acceptor (pEC50< 6.0) and no liabilities at the hERG channel.
GSK962040 possesses highly excellent pharmacokinetic profiles in both rat and dog.

Physicochemical Properties

M.Wt 424.5541
Formula C25H33FN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: 12.73 mg/mL (Need ultrasonic)

Chemical Name/SMILES

Ethanone, 1-[4-[(3-fluorophenyl)amino]-1-piperidinyl]-2-[4-[[(3S)-3-methyl-1-piperazinyl]methyl]phenyl]-

References

1. Westaway SM, et al. J Med Chem. 2009 Feb 26;52(4):1180-9.

2. Sanger GJ, et al. Neurogastroenterol Motil. 2009 Jun;21(6):657-64, e30-1.

3. Broad J, et al. Br J Pharmacol. 2012 Oct;167(4):763-74.

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