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GSK962040 hydrochloride

Chemical Structure : GSK962040 hydrochloride

CAS No.: 923565-22-4

GSK962040 hydrochloride (Camicinal hydrochloride, GSK-962040 hydrochloride)

Catalog No.: PC-42739Not For Human Use, Lab Use Only.

GSK962040 (Camicinal) hydrochloride is a potent, selective, small molecule motilin receptor (GPR38) agonist with pEC50 of 7.9 (hMTL-R).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GSK962040 (Camicinal) hydrochloride is a potent, selective, small molecule motilin receptor (GPR38) agonist with pEC50 of 7.9 (hMTL-R).
GSK962040 displays selectivity over closely related human ghrelin acceptor (pEC50< 6.0) and no liabilities at the hERG channel.
GSK962040 possesses highly excellent pharmacokinetic profiles in both rat and dog.

Physicochemical Properties

M.Wt 461.0151
Formula C25H34ClFN4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Ethanone, 1-[4-[(3-fluorophenyl)amino]-1-piperidinyl]-2-[4-[[(3S)-3-methyl-1-piperazinyl]methyl]phenyl]-, hydrochloride (1:1)

References

1. Westaway SM, et al. J Med Chem. 2009 Feb 26;52(4):1180-9.

2. Sanger GJ, et al. Neurogastroenterol Motil. 2009 Jun;21(6):657-64, e30-1.

3. Broad J, et al. Br J Pharmacol. 2012 Oct;167(4):763-74.

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