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GSK963

Chemical Structure : GSK963

CAS No.: 2049868-46-2

GSK963 (GSK-963, GSK 963, GSK'963)

Catalog No.: PC-60549Not For Human Use, Lab Use Only.

GSK-963 (GSK963) is a potent and selective inhibitor of RIP1 kinase (RIPK1) with IC50 of 29 nM in FP binding assays.

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Biological Activity

GSK-963 (GSK963) is a potent and selective inhibitor of RIP1 kinase (RIPK1) with IC50 of 29 nM in FP binding assays.
GSK-963 displays excellent selectivity of against a panel of 339 kinases, including IDO.
GSK-963 efficiently blocks necroptosis in both murine and human cells with IC50 of 1 nM and 4 nM, respectively.
GSK-963 demonstrates much greater protection from hypothermia in model of TNF-induced sterile shock, compared with Necrostatin-1.

Physicochemical Properties

M.Wt 230.311
Formula C14H18N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,2-Dimethyl-1-(5(S)-phenyl-4,5-dihydro-pyrazol-1-yl)-propan-1-one

References

1. Berger SB, et al. Cell Death Discov. 2015 Jul 27;1:15009.

2. Rojas-Rivera D, et al. Cell Death Differ. 2017 Jun;24(6):1100-1110.

3. Lule S, et al. Stroke. 2017 Sep;48(9):2549-2556.

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