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Chemical Structure : GSM-1
CAS No.: 884600-68-4
Catalog No.: PC-35113Not For Human Use, Lab Use Only.
GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay.
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|---|---|---|---|
| 2 mg | $248 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $598 | In stock | |
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| 100 mg | Get quote |
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GSM-1 (GSM1) is a γ-secretase modulator that directly targets the transmembrane domain (TMD) 1 of presenilin 1, shows potent Aβ42-lowering effect (IC50=0.348 uM) in a cell-based assay.
GSM-1 does not affect total Aβ and its C-terminal counterpart product, APP intracellular domain (AICD), selectively reduced the Aβ42 generation accompanied by an increase in Aβ38 in in-vitro assay.
GSM-1 decreases the ratio of Aβ42 to Aβ40 to 60% in plasma and the ratio of Aβ42 to total Aβ to 65% in cerebrospinal fluid from baseline to postdosing in monkeys (30 mg/kg)
| M.Wt | 481.98 | |
| Formula | C26H31ClF3NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((2S,4R)-1-((R)-1-(4-chlorophenyl)-4-methylpentyl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid |
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1. Page RM, et al. J Biol Chem. 2010 Jun 4;285(23):17798-810.
2. Kretner B, et al. J Biol Chem. 2011 Apr 29;286(17):15240-51.
3. Ohki Y, et al. EMBO J. 2011 Oct 14;30(23):4815-24.
4. Ling IF, et al. Alzheimers Res Ther. 2015 Aug 5;7(1):55.
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