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GSM-2

Chemical Structure : GSM-2

CAS No.: 956465-56-8

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GSM-2 (GSM2)

Catalog No.: PC-62913Not For Human Use, Lab Use Only.

GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GSM-2 is a second-generation γ-secretase modulator (GSM) that only decreases Aβ42 (IC50=65.2 nM), while inversely increasing Aβ38 and having no effect on β-CTF and Aβ40 levels.
    GSM-2 significantly ameliorates memory deficits in Tg2576 mice and does not affect normal cognition in wild-type mice.

    Physicochemical Properties

    M.Wt 467.5
    Formula C23H31F6NO2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((2S,4R)-1-((R)-1,1,1-trifluoro-7-methyloctan-4-yl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid

    References

    1. Mitani Y, et al. J Neurosci. 2012 Feb 8;32(6):2037-50.

    2. Robertson AS, et al. Eur J Pharmacol. 2017 Oct 5;812:104-112.

    3. Mitani Y, et al. J Neurochem. 2013 May;125(3):465-72.

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