GSM-776890 | γ-secretase modulator | Probechem Biochemicals

Chemical Structure : GSM-776890

GSM-776890 (UCSD-776890)

Catalog No.: PC-22499Not For Human Use, Lab Use Only.

UCSD-776890 (UCSD-776890) is a potent, selective γ-secretase modulator with Aβ42 IC50 of 4.2 nM, Aβ40 IC50 of 80 nM, also shows EC50 of 18 nM for potentiating Aβ38 secretion.

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Biological Activity

UCSD-776890 (UCSD-776890) is a potent, selective γ-secretase modulator with Aβ42 IC50 of 4.2 nM, Aβ40 IC50 of 80 nM, also shows EC50 of 18 nM for potentiating Aβ38 secretion.

Physicochemical Properties

M.Wt	436.47
Formula	C23H22F2N6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(3,5-difluorophenyl)ethyl)-6-(6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridin-2-yl)-4-methylpyridazin-3-amine

References

1. Kevin D Rynearson, et al. J Exp Med. 2021 Apr 5;218(4):e20202560.

2. Pettersson M, et al. J Med Chem. 2024 Jun 7. doi: 10.1021/acs.jmedchem.4c00580.

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GSM-776890 (UCSD-776890)

Biological Activity

Physicochemical Properties

References

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