GSTO1 inhibitor KT53

Chemical Structure : GSTO1 inhibitor KT53

Catalog No.: PC-25453Not For Human Use, Lab Use Only.

GSTO1 inhibitor KT53 is a potent, selective and cell-active inhibitor of glutathione S-transferase omega 1 (GSTO1-1) with IC50 of 21 nM in vitro and 35 nM in situ.

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Biological Activity

GSTO1 inhibitor KT53 is a potent, selective and cell-active inhibitor of glutathione S-transferase omega 1 (GSTO1-1) with IC50 of 21 nM in vitro and 35 nM in situ.
KT53 sensitizes cancer cells to the cytotoxic effects of cisplatin.

Physicochemical Properties

M.Wt	403.88
Formula	C21H23ClFN3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(2-(cyclohexylamino)-2-oxo-1-(pyridin-2-yl)ethyl)-N-(3-fluorophenyl)acetamide

References

1. Tsuboi K, et al. J Am Chem Soc. 2011 Oct 19;133(41):16605-16.

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