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Chemical Structure : GT951
Catalog No.: PC-49853Not For Human Use, Lab Use Only.
GT951 (GT-951) is a potent, selective activator (positive allosteric modulator) of EAAT2 with EC50 of 0.8 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
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GT951 (GT-951) is a potent, selective activator (positive allosteric modulator) of EAAT2 with EC50 of 0.8 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
GT951 demonstrats high potency to EAAT2 in the in vitro glutamate uptake assays in primary astrocytes with EC50 of 0.3 nM.
GT951 displays high selectivity to EAAT2 in comparison to other EAATs and did not have any functional effects on NMDA-mediated calcium response.
GT951 is a noncompetitive positive allosteric stimulator of EAAT2, specifically stimulates EAAT2-mediated transport and does not alter EAAT1- and EAAT3-mediated transport.
| M.Wt | 589.62 | |
| Formula | C31H30F3N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sandhya Kortagere, et al. ACS Chem Neurosci. 2018 Mar 21;9(3):522-534.
2. Sanjay Da, et al. ACS Med Chem Lett. 2022 Sep 19;13(10):1628-1633.
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