GTS-21 | α7 nAChR agonist | Probechem Biochemicals

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Chemical Structure : GTS-21

GTS-21 (DMXBA, DMBX-anabaseine)

Catalog No.: PC-23863Not For Human Use, Lab Use Only.

GTS-21 (DMXBA) is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist, is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.
GTS-21 (DMXBA) shows anti‑inflammatory and cognition‑enhancing activities.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	308.38
Formula	C19H20N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine

References

1. Meyer EM, et al. J Pharmacol Exp Ther. 1998 Dec;287(3):918-25.

2. Woodruff-Pak DS, et al. Brain Res. 1994 May 9;645(1-2):309-17.

3. Briggs CA, et al. Pharmacol Biochem Behav. 1997;57(1-2):231-241.

4. Zhang R, et al. J Pharmacol Exp Ther. 2006;317(3):1276-1284.

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GTS-21 (DMXBA, DMBX-anabaseine)

Biological Activity

Physicochemical Properties

References

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