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Chemical Structure : GTS467
Catalog No.: PC-49856Not For Human Use, Lab Use Only.
GTS476 (GTS-476) is a potent, selective, orally active activator of EAAT2 with EC50 of 35.1 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
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GTS476 (GTS-476) is a potent, selective, orally active activator of EAAT2 with EC50 of 35.1 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
GTS467 has high oral bioavailability (80–85%) in the brain and plasma with a >1 h half-life under all three dosing routes ((intraperitoneal, IP, at 10 mg/kg; postoral, PO, at 10 mg/kg; and intravenous, IV, at 5 mg/kg).
| M.Wt | 396.49 | |
| Formula | C22H28N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sanjay Da, et al. ACS Med Chem Lett. 2022 Sep 19;13(10):1628-1633.
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