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Chemical Structure : GTS511
Catalog No.: PC-49854Not For Human Use, Lab Use Only.
GTS511 (GTS-511) is a potent, selective, brain-permeable activator of EAAT2 with EC50 of 3.8 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
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GTS511 (GTS-511) is a potent, selective, brain-permeable activator of EAAT2 with EC50 of 3.8 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
GTS511 show a >6 h half-life and higher bioavailability in plasma and the brain under all three routes of administration in rats (intraperitoneal, IP, at 10 mg/kg; postoral, PO, at 10 mg/kg; and intravenous, IV, at 5 mg/kg).
| M.Wt | 339.40 | |
| Formula | C19H21N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sanjay Da, et al. ACS Med Chem Lett. 2022 Sep 19;13(10):1628-1633.
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