Chemical Structure : GW117
CAS No.:
2260629-83-0
GW117
(GW-117)
Catalog No.: PC-22026Not For Human Use, Lab Use Only.
GW117 is a novel serotonin (5-HT2C) receptor antagonist and melatonin (MT1 /MT2 ) receptor agonist with Ki values of 0.32, 0.12, and 54 nM, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GW117 is a novel serotonin (5-HT2C) receptor antagonist and melatonin (MT1 /MT2 ) receptor agonist with Ki values of 0.32, 0.12, and 54 nM, respectively.
GW117 stimulates specific [35S]‐GTPγS binding with an EC50 of 2.49 nM and 1.54 nM and a maximal increase over basal binding (% Emax) of 104 ± 7.34% and 103.2 ± 4.56% on the MT1 receptor and MT2 receptor, respectively.
GW117 dose‐dependently blocked activation of [35S]‐GTPγS binding and [3H]PIP released by 10 nM 5‐HT.
GW117 (20, and 40 mg/kg, p.o.) markedly reduced the immobility time on TST test in mice, showed potential antidepressant‐like activity.
Physicochemical Properties
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M.Wt
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280.77
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Formula
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C15H13D3ClNO2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(2-(6-chloro-7-(methoxy-d3)naphthalen-1-yl)ethyl)acetamide
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References
1. Gao N, et al. CNS Neurosci Ther. 2021 Jun;27(6):702-713.
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