GW274150 is a potent and highly selective inhibitor of iNOS with IC50 of 1.4 uM, displays >200 fold selectivity over eNOS and nNOS (IC50>100 uM).
GW274150 attenuates the degree of chronic inflammation and tissue damage associated with collagen-induced arthritis in mice.
GW274150 significantly reduces serum urea, serum creatinine, AST, and NAG, reduces experimental renal ischemia/reperfusion injury.
Physicochemical Properties
M.Wt
219.3045
Formula
C8H17N3O2S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
H2O: ≥ 62 mg/mL
Chemical Name/SMILES
L-Homocysteine, S-[2-[(1-iminoethyl)amino]ethyl]-
References
1. Young RJ, et al. Bioorg Med Chem Lett. 2000 Mar 20;10(6):597-600.
2. Cuzzocrea S, et al. Eur J Pharmacol. 2002 Oct 18;453(1):119-29.
