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GW311616A

Chemical Structure : GW311616A

CAS No.: 198062-54-3

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GW311616A (GW-311616A)

Catalog No.: PC-49568Not For Human Use, Lab Use Only.

GW311616A is a potent, specifc intracellular and orally active inhibitor of human neutrophil elastase (HNE) with Ki of 0.31 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GW311616A is a potent, specifc intracellular and orally active inhibitor of human neutrophil elastase (HNE) with Ki of 0.31 nM.
    GW311616A significantly reduced injury-induced neointimal hyperplasia (NIH) in both neutrophil elastase-deficient mice and mice.
    GW311616A reversed insulin resistance and body weight gain in HFD-fed mice.

    Physicochemical Properties

    M.Wt 397.53
    Formula C19H31N3O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3S,3aS,6aR)-Hexahydro-3-(1-methylethyl)-1-(methylsulfonyl)-4-[(2E)-1-oxo-4-(1-piperidinyl)-2-buten-1-yl]pyrrolo[3,2-b]pyrrol-2(1H)-one

    References

    1. Macdonald SJ, et al. Bioorg Med Chem Lett. 2001 Apr 9;11(7):895-8.

    2. Mansuy-Aubert V, et al. Cell Metab. 2013 Apr 2;17(4):534-48.

    3. Mei Yang, et al. Br J Pharmacol. 2021 Oct;178(20):4048-4068.

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