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GW441756

Chemical Structure : GW441756

CAS No.: 504433-23-2

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GW441756 (GW-441756, GW 441756)

Catalog No.: PC-45453Not For Human Use, Lab Use Only.

GW441756 is a potent, specific TrkA inhibitor with IC50 value of 2 nM.

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5 mg (Free Sample) $28 In stock
25 mg $128 In stock
50 mg $198 In stock
100 mg $328 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GW441756 is a potent, specific TrkA inhibitor with IC50 value of 2 nM.
GW441756 shows no significant inhibition on CDK2 and c-Raf1 (IC50> 7 uM).
GW441756 blockes gammaH2AX production and decreases ES cell proliferation.

Physicochemical Properties

M.Wt 275.3046
Formula C17H13N3O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: < 11.2 mg/mL
Chemical Name/SMILES

2H-Pyrrolo[3,2-b]pyridin-2-one, 1,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-

References

1. Wood ER, et al. Bioorg Med Chem Lett. 2004 Feb 23;14(4):953-7.

2. Heinen TE, et al. Oncotarget. 2016 Jun 7;7(23):34860-80.

3. Jung EJ, et al. Mol Cells. 2008 Jul 31;26(1):12-7.

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