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GW 5074

Chemical Structure : GW 5074

CAS No.: 220904-83-6

GW 5074 (10O5, GW-5074, GW5074)

Catalog No.: PC-42645Not For Human Use, Lab Use Only.

GW 5074 (10O5) is a potent, selective c-Raf inhibitor with IC50 of 9 nM, also is a alkenyl oxindole molecular glue that tether mHTT to LC3 (Kd=467 nM), enabling the lysosomal degradation of mHTT.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GW 5074 (10O5) is a potent, selective c-Raf inhibitor with IC50 of 9 nM, also is a alkenyl oxindole molecular glue that tether mHTT to LC3 (Kd=467 nM), enabling the lysosomal degradation of mHTT.
GW 5074 shows >1000-fold selectivity for raf kinase versus CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms.

Physicochemical Properties

M.Wt 520.942
Formula C15H8Br2INO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-

References

1. Lackey K, et al. Bioorg Med Chem Lett. 2000 Feb 7;10(3):223-6.
2. Yue X, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):57-9.
3. Jensen HA, et al. Cell Signal. 2015 Aug;27(8):1666-75.
4. Li Z, et al. Nature. 2019 Nov;575(7781):203-209.

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