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Chemical Structure : GW 5074
CAS No.: 220904-83-6
Catalog No.: PC-42645Not For Human Use, Lab Use Only.
GW 5074 (10O5) is a potent, selective c-Raf inhibitor with IC50 of 9 nM, also is a alkenyl oxindole molecular glue that tether mHTT to LC3 (Kd=467 nM), enabling the lysosomal degradation of mHTT.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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GW 5074 (10O5) is a potent, selective c-Raf inhibitor with IC50 of 9 nM, also is a alkenyl oxindole molecular glue that tether mHTT to LC3 (Kd=467 nM), enabling the lysosomal degradation of mHTT.
GW 5074 shows >1000-fold selectivity for raf kinase versus CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms.
| M.Wt | 520.942 | |
| Formula | C15H8Br2INO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo- |
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