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Chemical Structure : GW627368
CAS No.: 439288-66-1
Catalog No.: PC-45103Not For Human Use, Lab Use Only.
GW627368 is a potent and selective competitive antagonist of prostanoid EP4 receptor with pKi of 7.0.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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GW627368 is a potent and selective competitive antagonist of prostanoid EP4 receptor with pKi of 7.0.
GW627368 also binds to human prostanoid TP receptors (pKi=6.8) but not the TP receptors of other species.
GW627368 produces 100% inhibition of U-46619 (EC100)-induced aggregation at 10 uM (pA2=7.0).
GW627368 also inhibits proliferation and induces apoptosis in cervical cancer by interfering with EP4/EGFR interactive signaling.
| M.Wt | 544.6181 | |
| Formula | C30H28N2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzeneacetamide, 4-(4,9-diethoxy-1,3-dihydro-1-oxo-2H-benz[f]isoindol-2-yl)-N-(phenylsulfonyl)- |
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1. Wilson RJ, et al. Br J Pharmacol. 2006 Jun;148(3):326-39.
2. Parida S, et al. Cell Death Dis. 2016 Mar 24;7:e2154.
3. Parida S, et al. Cancer Biol Ther. 2015;16(6):922-32.
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