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Chemical Structure : GW 803430
Catalog No.: PC-61120Not For Human Use, Lab Use Only.
A potent, specific, orally active melanin concentrating hormone receptor 1 (MCHR1) inhibitor with kI of 3.8 nM, >100-fold selectivity over a battery of GPCRs, ion channels and enzymes.
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A potent, specific, orally active melanin concentrating hormone receptor 1 (MCHR1) inhibitor with kI of 3.8 nM, >100-fold selectivity over a battery of GPCRs, ion channels and enzymes; produces robust antidepressant-like response in mice (0.3 and 1 mg/kg p.o.), also significantly reduces submissive behaviors and shows anxiolytic-like effects in vivo.
| M.Wt | 481.995 | |
| Formula | C25H24ClN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gehlert DR, et al. J Pharmacol Exp Ther. 2009 May;329(2):429-38.
2. Cippitelli A, et al. Psychopharmacology (Berl). 2010 Sep;211(4):367-75.
3. Zhang LN, et al. Obesity (Silver Spring). 2014 Mar;22(3):681-90.
4. Hertzog DL, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4723-7.
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