GX-674 |CAS:1432913-36-4 Probechem Biochemicals

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Chemical Structure : GX-674

GX-674 (GX674)

Catalog No.: PC-62323Not For Human Use, Lab Use Only.

GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM.
GX-674 inhibits Nav1.7 with much higher potency than most other Nav isoforms: Nav1.7 ~ Nav1.2 > Nav1.6 >>Nav1.1 > Nav1.8 > Nav1.3 > Nav1.4 ~ Nav1.5, and 100,000 times greater than that of the cardiac isoform Nav1.5.

Physicochemical Properties

M.Wt	534.941
Formula	C21H13ClF2N6O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-(2-Amino-1H-benzo[d]imidazol-5-yl)-4-chlorophenoxy)-2,5-difluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

References

1. Ahuja S, et al. Science. 2015 Dec 18;350(6267):aac5464.

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GX-674 (GX674)

Biological Activity

Physicochemical Properties

References

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