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Chemical Structure : GX-674
Catalog No.: PC-62323Not For Human Use, Lab Use Only.
GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM.
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GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM.
GX-674 inhibits Nav1.7 with much higher potency than most other Nav isoforms: Nav1.7 ~ Nav1.2 > Nav1.6 >>Nav1.1 > Nav1.8 > Nav1.3 > Nav1.4 ~ Nav1.5, and 100,000 times greater than that of the cardiac isoform Nav1.5.
| M.Wt | 534.941 | |
| Formula | C21H13ClF2N6O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ahuja S, et al. Science. 2015 Dec 18;350(6267):aac5464.
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