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Chemical Structure : GYKI 52466 dihydrochloride
Catalog No.: PC-61725Not For Human Use, Lab Use Only.
GYKI 52466 is a selective, non-competitive, orally active AMPA receptor (AMPAR) antagonist with IC50 of 10-20 uM against AMPA-induced responses.
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GYKI 52466 is a selective, non-competitive, orally active AMPA receptor (AMPAR) antagonist with IC50 of 10-20 uM against AMPA-induced responses.
GYKI 52466 displays >20-fold selectivity over kainate and NMDA receptors.
GYKI 52466 shows anticonvulsant and neuroprotective properties.
| M.Wt | 366.24 | |
| Formula | C17H15N3O2.2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tarnawa I, et al. Eur J Pharmacol. 1989 Aug 22;167(2):193-9.
2. Ouardouz M, et al. Neurosci Lett. 1991 Apr 15;125(1):5-8.
3. Donevan SD, et al. Neuron. 1993 Jan;10(1):51-9.
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