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GYKI 52466 dihydrochloride

Chemical Structure : GYKI 52466 dihydrochloride

CAS No.: 102771-26-6

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GYKI 52466 dihydrochloride (GYKI52466 dihydrochloride)

Catalog No.: PC-61725Not For Human Use, Lab Use Only.

GYKI 52466 is a selective, non-competitive, orally active AMPA receptor (AMPAR) antagonist with IC50 of 10-20 uM against AMPA-induced responses.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GYKI 52466 is a selective, non-competitive, orally active AMPA receptor (AMPAR) antagonist with IC50 of 10-20 uM against AMPA-induced responses.
    GYKI 52466 displays >20-fold selectivity over kainate and NMDA receptors.
    GYKI 52466 shows anticonvulsant and neuroprotective properties.

    Physicochemical Properties

    M.Wt 366.24
    Formula C17H15N3O2.2HCl
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenamine dihydrochloride

    References

    1. Tarnawa I, et al. Eur J Pharmacol. 1989 Aug 22;167(2):193-9.

    2. Ouardouz M, et al. Neurosci Lett. 1991 Apr 15;125(1):5-8.

    3. Donevan SD, et al. Neuron. 1993 Jan;10(1):51-9.

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