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Chemical Structure : GZ389988
Catalog No.: PC-35954Not For Human Use, Lab Use Only.
GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis.
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GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis.
GZ389988 shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R).
GZ389988 is highly selective against a wide panel of other kinases.
GZ389988 can significantly reduces local joint pain, without effect on ipsilateral joint pain.
GZ389988 also is efficacious in the PGPS arthritis model, demonstrating a significant improvement of gait analysis scores following painful disease reactivation flares.
| M.Wt | 470.533 | |
| Formula | C26H26N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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