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GZ389988

Chemical Structure : GZ389988

CAS No.: 1788906-96-6

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GZ389988 (GZ-389988, GZ 389988)

Catalog No.: PC-35954Not For Human Use, Lab Use Only.

GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GZ389988 (GZ-389988) is a novel potent, selective, locally delivered TrkA inhibitor for the treatment osteoarthritis.
    GZ389988 shows similar IC50 values for TrkA, TrkB and TrkC, and the growth factor receptor cFMS (CSF1R).
    GZ389988 is highly selective against a wide panel of other kinases.
    GZ389988 can significantly reduces local joint pain, without effect on ipsilateral joint pain.
    GZ389988 also is efficacious in the PGPS arthritis model, demonstrating a significant improvement of gait analysis scores following painful disease reactivation flares.

    Physicochemical Properties

    M.Wt 470.533
    Formula C26H26N6O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine

    References

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