A potent allosteric potentiating ligand of human nAChRs α4β2, α3β4, and α6β4; potentiates agonist responses of the four nAChR subtypes at 0.1-1 uM, acts as an nAChR inhibitor at >10 uM; also shows affinity for chicken/mouse nAChRs α7/5-HT3 in certain areas of the brain; also works as a weak competitive and reversible cholinesterase inhibitor with IC50 of 2.8-3.2 uM; decreases genotoxicity and cell death induced by β-amyloid peptide in SH-SY5Y cell line.
