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Chemical Structure : Galanthamine
CAS No.: 357-70-0
Catalog No.: PC-45968Not For Human Use, Lab Use Only.
A potent allosteric potentiating ligand of human nAChRs α4β2, α3β4, and α6β4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 100 mg | $64 | In stock |
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A potent allosteric potentiating ligand of human nAChRs α4β2, α3β4, and α6β4; potentiates agonist responses of the four nAChR subtypes at 0.1-1 uM, acts as an nAChR inhibitor at >10 uM; also shows affinity for chicken/mouse nAChRs α7/5-HT3 in certain areas of the brain; also works as a weak competitive and reversible cholinesterase inhibitor with IC50 of 2.8-3.2 uM; decreases genotoxicity and cell death induced by β-amyloid peptide in SH-SY5Y cell line.
Alzheimer's Disease
Approved
| M.Wt | 287.3535 | |
| Formula | C17H21NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 59 mg/mL |
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| Chemical Name/SMILES |
6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, (4aS,6R,8aS)- |
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1. Samochocki M, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1024-36.
2. Woodruff-Pak DS, et al. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2089-94.
3. Bloniecki V, et al. J Alzheimers Dis. 2017;57(2):387-393.
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