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Chemical Structure : Gallotannin
CAS No.: 5424-20-4
Catalog No.: PC-62410Not For Human Use, Lab Use Only.
Gallotannin (Tannic acid, Gallotannic acid) is a potent PARG (poly(ADP-ribose) glycohydrolase) inhibitor that produces significant reductions in H2O2-induced cell death in cultured murine astrocytes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 500 mg | $58 | In stock | |
| 1 g | $88 | In stock | |
| 5 g | Get quote |
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Gallotannin (Tannic acid, Gallotannic acid) is a potent PARG (poly(ADP-ribose) glycohydrolase) inhibitor that produces significant reductions in H2O2-induced cell death in cultured murine astrocytes.
Gallotannin (Tannic acid, Tannin) prevents PARP1-mediated cell death by slowing the turnover of poly(ADP-ribose) and thus slowing NAD(+) consumption.
Gallotannin (Tannic acid, Tannin) increases endogenous DNA damage, stalls replication forks and increases homologous recombination.
| M.Wt | 1701.2 | |
| Formula | C76H52O46 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
[2,3-dihydroxy-5-[[(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]oxan-2-yl]methoxycarbonyl]phenyl] 3,4,5-trihydroxybenzoate |
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1. Ying W, et al. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12227-32.
2. Ying W, et al. Neuroreport. 2000 May 15;11(7):1385-8.
3. Fathers C, et al. Cell Cycle. 2012 Mar 1;11(5):990-7.
4. Formentini L, et al. Br J Pharmacol. 2008 Dec;155(8):1235-49.
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